Dynamics of clinical and biochemical parameters as a criterion for the severity of acute pancreatitis

Introduction. Analysis of modern literature data made it possible to establish key clinical and biochemical parameters that determine the severity of acute pancreatitis. A comprehensive dynamic assessment of these indicators in patients with this pathology revealed their clear relationship with the progression of the disease and the development of complications.Purpose of the study. To evaluate the dynamics of clinical and biochemical parameters as a criterion for the severity of acute pancreatitis.Materials and methods of research. The work is methodological in nature. The work used theoretical and empirical methods: analysis of literary sources, generalization, systematization, classification. A meta-analysis of available literature sources was carried out, as well as their comparison with the results of our own research.Treatment results. The increase in organ dysfunction, developing into multiple organ failure, the formation of destructive local changes in the pancreas, the aggravation of the systemic inflammatory reaction, impaired microcirculation and hemodynamics, as well as the addition of infectious complications are naturally associated with aggravation of the patients’ condition. In parallel with clinical manifestations, the progression of acute pancreatitis is accompanied by characteristic changes in biochemical parameters. There is an increase in markers of cellular and tissue damage.Conclusion. A comprehensive analysis of the dynamics of clinical and biochemical parameters in patients with acute pancreatitis makes it possible to timely identify patients with a high risk of developing severe disease and complications, which necessitates a differentiated approach to diagnostic and treatment tactics.