Dynamics of oxidative modification of proteins and lipids of blood plasma in alcoholic patients in the process of the therapy

Objective: to evaluate dynamics of oxidative status in patients in the process of antialcohol therapy for development of ideas about oxidative stress in the clinical picture of alcoholism. Materials and Methods: The study enrolled 46 male alcoholic patients (F10.302) and 34 healthy men (control group). For evaluation of oxidative status of patients at baseline and after therapy blood plasma was used for determining the content of products of the protein oxidative modification (POM), measuring carbonylated proteins, and products of lipid peroxidation (LP), using thiobarbituric acid. Results: In patients with severe oxidative stress at baseline the therapy contributed to its reduction. In patients without signs of oxidative stress at baseline after antialcohol therapy the induction of oxidative modification of proteins and lipids in blood plasma was possible. Conclusion: In the process of antialcohol therapy in different groups of patients with different initial oxidative status, change of markers of oxidative stress occurred differently directed: in patient without state of oxidative stress during therapy its induction could occur while in case of severe oxidative stress its reduction occurred in the process of personalized antioxidant therapy.