Dynamics of pneumonia development at wild type mice and mice, deprived of surfactant protein A (SP-A) gene, after ozone inhalation

Tropospheric ozone is one of factors of the anthropogenous air pollution, making considerable impact on population health. The surfactant protein And (SP-A, Surfactant Protein A) carries out protective function in lungs. We have shown earlier that females of mice were steadier against pneumonia, than males for lack of ozone inhalation whereas after inhalation of ozone the trend changed on opposite – the survival of females was at lower level, than survival of males after pneumonia. We also have shown earlier that the mice, deprived of SP-A gene, were more sensitive to pneumonia, than the mouse of wild type. The purpose of the given work: studying the reasons of various level of survival rate of mice after pneumonia by the analysis of dynamics of pulmonary infection development after ozone inhalation. The received results testify that higher levels of bacteria reproduction in lungs and lowered immune answer of spleen at females infected with pneumonia after ozone inhalation, and higher level of infections dissemination at males in absence of ozone treatment, are the factors defining level of mice survival from pneumonia at presence or absence of oxidizing stress, caused by ozone inhalation.