Dynamics of the influence of NPY on amplitude-temporal indicators of isometric contraction of atrial myocardium

The purpose of the study was to study the dynamics of the influence of neuropeptide Y (NPY) on the frequency and amplitude-time parameters of isometric contraction of the atrial myocardium of rats in early postnatal ontogenesis. In this work, we studied the effect of a non-selective NPY agonist on the frequency of spontaneous activity and contractility of the rat atrial myocardium at different stages of the formation of sympathetic innervation. NPY in 7-day-old animals has a multidirectional effect on the frequency of spontaneous activity and significantly reduces it in 100-day-old animals. The main parameters of isometric reduction are reduced with the addition of NPY compared to control values.