Dysfunction of vascular endothelium and its correction in young patients with essential hypertension and stable angina

The aim of the study was to examine abnormalities in the function of vascular endothelium in young patients with essential hypertension and stable angina. The study included 136 young patients with essential hypertension and stable angina and 30 healthy persons. In young patients with essential hypertension and stable angina, the study revealed the signs of endothelial dysfunction characterized by low levels of endothelin-1 and thromboxane in the presence of reduced synthesis of NO, prostaglandin E2, and guanylate monophosphate. Standard medical treatment and treatment with liposomal drugs did not affect the levels of vasoactive substances. Combined treatment with hypoxytherapy contributed to improvement of endothelial function, namely: statistically significant reduction of endothelin-1 production and increased excretion of nitric oxide.