Long-term effects of new coronavirus infection (COVID-19) in patients with chronic coronary syndromes in real clinical practice

Objective: to assess the dynamics of hemodynamic, metabolic, hematological parameters and myocardial contractility markers in patients with chronic coronary syndromes who have undergone a new coronavirus infection (COVID- 19), according to the time since its manifestation. Material and Methods. The one-center observational study of patients with chronic coronary syndromes (CCS) who underwent COVID-19 (1–10 months, n=138) was carried out. assessment of The basic clinical, laboratory and instrumental parameters were assessed depending on the time since COVID-19 manifestation. To assess the duration of post-COVID changes in continuous variable, the deviation index from normal values was calculated. Results. The median duration of the post-COVID changes in the studied parameters was 4 months. In patients with CCS, against the background of a relatively constant amount of total protein, there was an increase in the level of albumin by 12.3 (11.5; 25.1) %, with minimal values in patients survived COVID-19 within a month, p=0.008. The decrease in the leukocytes count was revealed with minimum by the 10th month since the COVID-19 manifestation: 9.0 (6.4; 10.9), *108 / L (1 month) to 5.5 (4.9; 6.1), *108 / L (10 months), p=0.001. Heart rate decreased by 28.2 (22.1; 31.1) %, p=0.001, and was accompanied by the left ventricular ejection fraction augmentation from 58 (59; 64) % (1 month) to 69 (67; 71) % (10 months), p=0.027. Conclusion. In patients with chronic coronary syndromes, the main long-term trends of post-COVID changes in metabolic, hematological, ECG parameters and characteristics of myocardial contractility, routinely determined in real clinical practice, were revealed