Energy phenotypes of BT20, BT474, MDA-MB-453 under actions and effects made by berberine

Breast cancer (BC) is among most cancers worldwide. To date, research is being actively conducted to study substances that can influence on the phenotype of the tumor cells. In chemotherapy with various drugs, the tumor cells have an ATP deficiency that contributes to a decrease in their proliferative activity. In the course of numerous pharmacological studies, the natural compound berberine isolated from the roots of plants of the genus Berberis sp. [1] has engaged the researchers' attention as a candidate for this purpose. The aim of our study was to explore the actions and effects produced by berberine on the energy phenotypes of breast cancer cell lines BT20, BT474 and MDA-MB-453.