Evaluation of cytotoxicity and pro-apoptotic effects of new CYP17A1 inhibitors
Автор: Khan I.I., Aidosov Ch.M., Krivchenko V.O., Latysheva A.S., Zolottsev V.A., Misharin A.Yu., Pokrovsky V.S.
Журнал: Cardiometry @cardiometry
Статья в выпуске: 24, 2022 года.
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The CYP17A1 inhibitors are used to treat castration-resistant prostate cancer. However, the existing shortcomings (side effects and low bio-availability) make the search, synthesis, and evaluation of the biological properties of new agents relevant. The aim of our research work was to investigate the cytotoxic and proapoptotic properties of new compounds: alsevirone and LA-91.
Короткий адрес: https://sciup.org/148326311
IDR: 148326311 | DOI: 10.18137/cardiometry.2022.24.conf.19
Список литературы Evaluation of cytotoxicity and pro-apoptotic effects of new CYP17A1 inhibitors
- Kostin V.A., et al. Oxazolinyl derivatives of [17(20)E]-21-norpregnene differing in the structure of A and B rings. Facile synthesis and inhibition of CYP17A1 catalytic activity. Steroids. 2016; 115: 114-122.
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