Pharmacoepidemiological study of non-steroid antiinflammatory medicine use in the in-patient department before and after the formular system adoption

We studied the use of non-steroid anti-inflammatory drugs (NSAID) at the in-patient department of central district hospital with the application of DDD-techniques before and after the formular system adoption. After introduction of drug formular and treatment standards the use of NSAID was reduced; the physicians began to use modern drugs. Non- indicated and contraindicated NSAID were prescribed more seldom. It was determined that reduction of antihypertensive drugs efficiency in hypertensive patients was the main side effect of NSAID use. NSAID gastropathy occurred more seldom, and mainly in the patients receiving several NSAIDs simultaneously.