Features of biochemical homeostasis in rats with anti-tumor effect produced by iron nanoparticles

Overloading a tumor with iron (Fe) is a promising strategy for cancer therapy. A number of papers have demonstrated a self-dependent anti-tumor effect of Fe nanoparticles (NPs) in vivo. However, an excessive amount of this trace metal can produce a negative effect on the organism. The aim of our study was to evaluate the metabolic changes in the rats with lymphosarcoma when exposed to FeNPs with anti-tumor activity.