Enzymatic markers of the tubules of the kidney in disturbed metabolism of bone tissue in hemophilia patients

Direct link between calcaruria stage and the activity of membrane-associated enzymes in the urine which points to injured action of the calcaruria on tubular part of nephron in patients having severe hemophilia is revealed. Standard laboratory methods of investigation do not reveal any changes but studying urine enzymes revealed injured tubular structures of nephron in most patients.