Физиологические эффекты Грелина

Автор: Логинова Ольга Александровна, Орлова Екатерина Григорьевна, Ширшев Сергей Викторович

Журнал: Вестник Пермского университета. Серия: Биология @vestnik-psu-bio

Статья в выпуске: 4, 2018 года.

Бесплатный доступ

Грелин - пептидный гормон, обладающий широким спектром эффектов в организме человека. Он принимает участие в регуляции энергетического и жирового обмена, ростовых процессов, полового созревания, половых циклов, беременности, в контроле поведенческих реакций, а также обладает выраженными иммуномодулирующими и противовоспалительными свойствами. В обзоре представлены данные о структуре грелина и его рецепторов, уровне гормона при физиологических и патологических состояниях, а также его основные биологические эффекты.

Грелин, рецептор грелина, грелин-о-ацилтрансфераза (гоат), эффекты грелина

Короткий адрес: https://sciup.org/147227053

IDR: 147227053 | DOI: 10.17072/1994-9952-2018-4-443-453

Список литературы Физиологические эффекты Грелина

рлова Е.Г. Регуляция лептином и грелином индукции Т-регуляторных лимфоцитов // Вестник Уральской медицинской академической науки. 2011. Т. 35, № 2/1. С. 55-56.
Орлова Е.Г., Ширшев С.В. Регуляция грелином функциональной активности моноцитов человека в модели in vitro // Доклады Академии наук. 2010. Т. 434(6). С. 821-824.
Орлова Е.Г., Ширшев С.В. Регуляция лептином и грелином продукции интерферона-гамма и интерлейкина-4 в системе in vitro // Вестник Пермского университета. 2012. Вып. 3. С. 81-83.
Орлова Е.Г., Ширшев С.В. Роль лептина и грелина в индукции дифференцировки ИЛ17-продуцирующих и Т-регуляторных лимфоцитов // Бюллетень экспериментальной биологии и медицины 2013. Т. 156, № 12. С. 786-791.
Романцова Т.И., Волкова Г.Е. Лептин и грелин: антагонизм и взаимодействие в регуляции энергетического обмена // Ожирение и метаболизм. 2005. № 2. С. 2-9.
Шестопалов А.В. и др. Грелин и соматотропный гормон при физиологически протекающей беременности // Журнал акушерства и женских болезней. 2011. № 2. С. 68-72.
Ширшев С.В. и др. Гормональная регуляция продукции IFN-g и IL-4 тимоцитами // Вестник Уральской медицинской академической науки. 2012. № 4(41). С. 76-77.
Ширшев С.В. и др. Роль гормонов, ассоциированных с гестацией, в регуляции экспрессии молекул, отвечающих за функциональную активность NK-клеток // Доклады Академии наук. 2014. Т. 457, № 5. C. 618-621.
Baatar D. et al. The effects of ghrelin on inflammation and the immune system // Molecular and Cellular Endocrinology. 2011. Vol. 340. P. 44-58.
Baldwin J.M. The probable arrangement of the helices in G protein-coupled receptors // The EMBO Journal. 1993 Vol. 12. P. 1693-1703.
Bockaert J., Pin J.P. Molecular tinkering of G protein-coupled receptors: An evolutionary success // The EMBO Journal. 1999. Vol. 18. P. 1723-1729.
Bowers C.Y. On a peptidomimetic growth hormonereleasing peptide // The Journal of Clinical Endocrinology & Metabolism 1994. Vol. 79. P. 940-942.
Cabral A. et al. Is ghrelin synthesized in the central nervous system? // International Journal of Molecular Sciences. 2017. Vol. 15, № 18 (3). ppi. E638.
Cekic C. et al. Evaluation of the relationship between serum ghrelin, Creactive protein and interleukin-6 levels, and disease activity in inflammatory bowel diseases // Hepatogastroenterology. 2008. Vol. 61, № 133. P. 1196-1200.
Chanoine J.P., Wong A.C. Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting // Endocrinology. 2004. Vol. 145. P. 3813-3820.
Collden G. et al. Therapeutic Potential of Targeting the Ghrelin Pathway // International Journal of Molecular Sciences. 2017. Vol. 18(4). pii: E798.
Cowley M.A. et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis // Neuron. 2003. Vol. 37. P. 649-661.
De Smet B. et al. Effect of peripheral obestatin on gastric emptying and intestinal contractility in rodents // Neurogastroenterology &Motility. 2007. Vol. 19. P. 211-217.
De Souza M.J. et al. Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones // The Journal of Clinical Endocrinology & Metabolism. 2004. Vol. 89. P. 3536-3542.
Delporte C. Structure and Physiological Actions of Ghrelin // Scientifica. 2013. 25 p.
Dhillo W.S. et al. The neuroendocrine physiology of kisspeptin in the human // Reviews in Endocrine and Metabolic Disorders. 2007. Vol. 8. P. 41-46.
Dixit V.D. et al. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells // The Journal of Clinical Investigation. 2004. Vol. 1. P. 57-66.
Dixit V.D. et al. Ghrelin promotes thymopoiesis during aging // The Journal of Clinical Investigation. 2007. Vol. 117, № 10. P. 2778-2790.
Dixit V.D., Taub D.D. Ghrelin and immunity: a young player in an old field // Experimental gerontology. 2005. Vol. 40. P. 900-910.
Diz Chaves Y. et al. GH responses to GHRH and GHRP-6 in Streptozotocin (STZ)-diabetic rats // Life Science. 2003. Vol. 14, № 73(26). P. 3375- 3385.
El-Eter E. et al. In vivo and in vitro antioxidant activity of ghrelin: Attenuation of gastric ischemic injury in the rat // Journal of Gastroenterology and Hepatology. 2007. Vol. 22, № 11. P. 1791-1799.
Fernandez G. et al. Des-acyl ghrelin directly targets the arcuate nucleus in a ghrelin-receptor independent manner and impairs the orexigenic effect of ghrelin // Neuroendocrinolology. 2016. Vol. 28, № 2. P. 205-219.
Fernández-Fernández R. et al. Novel signals for the integration of energy balance and reproduction // Molecular and Cellular Endocrinology. 2006. Vol. 25, № 254-255. P. 127-132.
Fernández-Fernández R. et al. Ghrelin effects on gonadotropin secretion in male and female // Neuroscience Letters. 2004. Vol. 362, № 2. P.103-107.
Fuglsang J. et al. Ghrelin and its relationship to growth hormones during normal pregnancy // Clinical Endocrinology. 2005. Vol. 62. P. 554-559.
Gnanapavan S. et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans // The Journal of Clinical Endocrinology & Metabolism. 2002. Vol. 87. P. 2988.
Gonzalez-Rey E. et al. Therapeutic action of ghrelin in a mouse model of colitis // Gastroenterology. 2006. Vol. 30. P. 1707-1720.
Granado M. et al. Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats // American Journal of Physiology-Endocrinology and Metabolism. 2005. Vol. 288. P. 486-492.
Gray P.C. et al. Regulation of ion channels by cAMPdependent protein kinase and A-kinase anchoring proteins // Current Opinion in Neurobiology. 1998. Vol. 8, № 4. P. 330-334.
Gregori S. Dendritic cells in networks of immunological tolerance // Tissue Antigens. 2011. Vol. 77. P. 89-99.
Gualillo O. et al. Ghrelin, a novel placental-derived hormone // Endocrinology. 2001. Vol. 142. P. 788-794.
Hattori N. Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system // Growth Hormone & IGF Research. 2009. Vol. 19. P. 187-197.
Hattori N. et al. GH, GH Receptor, GH Secretagogue Receptor, and Ghrelin Expression in Human T Cells, B Cells, and Neutrophils // The journal of Clinical Endocrinology & Metabolism. 2001. Vol. 86. P. 4284-4291.
Hosoda H. et al. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue // Biochemical and Biophysical Research Communications. 2000. Vol. 279, Iss. 3. P. 909-913.
Hosoda H. et al. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing // The Journal of Biological Chemistry. 2003. Vol. 278. P. 64-70.
Howard A.D. et al. A receptor in pituitary and hypothalamus that functions in growth hormone release // Science. 1996. Vol. 16, I.8. P. 974-977.
Kanamoto N. et al. Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene // Endocrinology. 2004. Vol. 145, № 9. P. 4144-4453.
Koch A. et al. Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis // Critical Care. 2010. Vol. 14. P. 94- 98.
Kojima M. et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach // Nature. 1999. Vol. 402. P. 656-660.
Kojima M., Kangawa K. Ghrelin: structure and function // Physiology Review. 2005. Vol. 85, № 2. P. 495-522.
Korbonits M. et al. Presence of ghrelin in normal and adenomatous human pituitary // Endocrine. 2001. Vol. 14. P. 101-104.
Korbonits M. et al. Ghrelin - a hormone with multiple functions // Frontiers in Neuroendocrinology. 2004. Vol. 25. P. 27-68.
Leung P.K. et al. The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor // Cellular Signaling. 2007. Vol. 19. P. 1011-1022.
Liu J. et al. Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men // The Journal of Clinical Endocrinology & Metabolism. 2008. Vol. 93. P. 1980-1987.
Mori K. et al. Kidney produces a novel acylated peptide, ghrelin // FEBS Letter. 2000. Vol. 486. P. 213-216.
Muccioli G. et al. Beyond the metabolic role of ghrelin: a new player in the regulation of reproductive function // Peptides. 2011. Vol. 32. P. 2514-2521.
Muccioli G. et al. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity // European Journal of Pharmacology. 2002. Vol. 440. P. 235-254.
Nagaya N. et al. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers // American journal of physiology. Regulatory, integrative and comparative physiology. 2001. Vol. 280. P. 1483-1487.
Nakahara K. et al. Maternal ghrelin plays an important role in rat fetal development during pregnancy // Endocrinology. 2006. Vol. 147. P. 1333- 1342.
Petersenn S. Structure and regulation of the growth hormone secretagogue receptor // Minerva Endocrinologica. 2002. Vol. 27. P. 243-256.
Pinto S. et al. Rapid rewiring of arcuate nucleus feeding circuits by leptin // Science. 2004. Vol. 304. P. 110-115.
Repasi A. et al. Ghrelin and reproductive disorders // Molecular and Cellular Endocrinology. 2011. Vol. 340. P. 70-79.
Smith R.G. et al. Peptidomimetic regulation of growth hormone secretion // Endocrine Reviews. 1997. Vol. 5. P. 621-645.
Soriano-Guillén L. et al. Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation // The Journal of Pediatrics. 2004. Vol. 144, № 1. P. 36-42.
Souza-Moreira L. et al. Therapeutic effect of ghrelin in experimental autoimmune encephalomyelitis by inhibiting antigen-specific Th1/Th17 responses and inducing regulatory T cells Brain // Behavior and Immunity. 2013. № 30. P. 54-60.
Spiegel K. et al. Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep // The journal of Clinical Endocrinology & Metabolism. 2011. Vol. 96, № 2. P. 486-493.
Stark R. et al. Des-acyl ghrelin and ghrelin Oacyltransferase regulate hypothalamic-pituitaryadrenal axis activation and anxiety in response to acute stress // Endocrinology. 2016. Vol. 157, № 10. P. 3946-3957.
Stasi C., Milani S. Functions of ghrelin in brain, gut and liver // CNS Neurological. Disorders - Drugs and Targets. 2016. Vol. 15, № 8. Р. 956-963.
Tena-Sempere M. Ghrelin as a pleotrophic modulator of gonadal function and reproduction // Nature clinical practice. Endocrinology & metabolism. 2008. Vol. 4, № 12. P. 666-674.
Tena-Sempere M. Ghrelin: novel regulator of gonadal function // Journal of. Endocrinology Investigation. 2005. Vol. 28, Suppl. 5. P. 26-29.
Trumpp-Kallmeyer S. et al. Towards understanding the role of the first extracellular loop for the binding of peptide hormones to G-protein coupled receptors // Pharmaceutica Acta Helvetiae. 1995. Vol. 70, № 3. P. 255-262.
Tschöp M. et al. Post-prandial decrease of circulating human ghrelin levels // Journal of Endocrinology Investigation. 2001. Vol. 24. P. 19-21.
Van der Lely A.J. et al. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin // Endocrine Reviews. 2004. Vol. 25. P. 426-457.
Viani I. et al. Ghrelin inhibits steroid biosynthesis by cultured granulosa-lutein cells // Journal of Clinical Endocrinology and Metabolism. 2008. Vol. 93. P. 1476-1481.
Watts V.J., Neve KA. Sensitization of adenylate cyclase by G-alpha i/o-coupled receptors // Pharmacology & Therapeutics. 2005. Vol. 106, № 3. P. 405-421.
Wellman M., Abizaid A. Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target // eNeuro. 2015. Vol. 2 (2). P. e005314.2015 1-16.
Wynne K. et al. Appetite control // Endocrinology. 2005. Vol. 184, № 2. P. 291-318.
Yildiz B.O. et al. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity // Proceedings of the National Academy of Sciences USA. 2004. Vol. 101, № 28. P. 10434- 10439.
Yuan M.J. et al. Potential new role of the GHSR-1amediated signaling pathway in cardiac remodeling after myocardial infarction (Review) // Oncology Letters. 2014. Vol. 8, № 3. P. 969-971.
Zhang J.V.O. et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake // Science. 2005. Vol. 310. P. 996-999.

Еще

Статья научная