Physiological and biochemical indicators of the blood of newborn calves in the application of sodium nucleinate to dry cows

The purpose of the work is to evaluate the physiological and biochemical parameters of the blood of newborn calves before and after feeding with colostrum when using sodium nucleinate to deep-calving cows 3-9 days before calving. The experiment was carried out in the autumn-winter period on a dairy farm of the agricultural production cooperative «Nizhegorodets» in the Nizhny Novgorod region. The objects of the study were 10 deep-calving black-and-white cows, selected on the principle of paired analogues, which were divided into 2 groups (control and experimental), 5 animals each, and newborn calves obtained from them. For 3-9 days before calving, cows of the experimental group were injected with a 0.2 % aqueous solution of sodium nucleinate at a dose of 5 ml intramuscularly, once. The cows of the control group were injected with 0.9 % sodium chloride solution. Sodium nucleinate is an immunomodulatory drug containing a mixture of sodium salts of nucleic acids obtained from a monoculture of baker's yeast Saccharomyces cerevisiae by biomass hydrolysis and its further purification. The use of sodium nucleinate intramuscularly in cows before calving at a dose of 5 ml leads to a significant increase in the number of leukocytes by 11.2-25.3 %, neutrophils and lymphocytes, the relative and absolute numbers of T-lymphocytes, total protein, albumin and gamma globulins in the resulting newborns calves one hour after drinking colostrum and on the second day of life.