Genetic and immunological markers of sensitivity and effect in potash production workers in the terms of combined risk factors’ impact

The evaluation of immunological and genetic markers in potash production workers has been performed. It was shown that under the combined impact of harmful factors (sylvite dust, noise) increased production of immune cytokine regulation markers was observed: tumor necrosis factor (TNFalfa) and vascular endothelial growth factor (VEGF), as well as a modified coding polymorphism of gene regions in the form of increased prevalence of variant alleles at the expense of minor homozygous (VEGF) and heterozygous (TNFalfa) genotypes. Detoxification genes’ polymorphism CYP1A1, CPOX characterizes the specific differences with the comparison group. Genes TNFalfa, VEGF, CYP1A1, CPOX are recommended as markers for susceptibility testing, and their encoded cytokines (tumor necrosis factor and vascular endothelial growth factor) as markers of effect in assessing health risk in potash production workers.