Гипотеза о возможных механизмах терапевтического действия гексанового экстракта Serenoa repens на состояние гипертрофированного мочевого пузыря в соответствии с патогенезом его дисфункции при инфравезикальной обструкции

Гипотеза о возможных механизмах терапевтического действия гексанового экстракта Serenoa repens на состояние гипертрофированного мочевого пузыря в соответствии с патогенезом его дисфункции при инфравезикальной обструкции

Автор: Сивков А.В., Кирпатовский В.И.

Журнал: Экспериментальная и клиническая урология @ecuro

Рубрика: Экспериментальная урология

Статья в выпуске: 2 т.16, 2023 года.

Бесплатный доступ

Введение. Традиционно считают, что терапевтическое действие гексанового экстракта Serenoa repens (HSRE) у пациентов с доброкачественной гиперплазией предстательной железы реализуется за счет его влияния на клетки предстательной железы (ПЖ). Однако в литературе имеются данные о возможном влиянии HSRE не только на ПЖ, но и непосредственно на мочевой пузырь. В данной работе обобщены эти данные и рассмотрены возможные клеточные механизмы действия HSRE на мочевой пузырь в условиях развития инфравезикальной обструкции (ИВО). Материалы и методы. Проанализированы данные литературы из баз PubMed и eLibrary.ru за 25-летний период, связанные с изучением патогенеза дисфункции мочевого пузыря при развитии ИВО, клеточных и молекулярных механизмов, посредством которых реализуются патологические и адаптационно-приспособительные процессы в клетках мочевого пузыря, а также влияние на эти процессы HSRE. Результаты. Высказана гипотеза о плейотропном влиянии HSRE на разные звенья патогенеза дисфункции мочевого пузыря, вызванной ИВО, основными из которых являются антиоксидантный и противовоспалительный эффекты компонентов HSRE, а также регулирующее действие на факторы роста и пролиферации клеток, как и факторы транскрипции. Все это уменьшает цитотоксический эффект оксидантного стресса на клетки мочевого пузыря развивающегося при ИВО, способствуя более активной пролиферации гладкомышечных клеток детрузора. Следствием комплексного действия является поддержание сократительной функции мочевого пузыря в состоянии адаптации к повышенной нагрузке вследствие ИВО. Заключение. Изложенная гипотеза о прямом действии HSRE на гипертрофированный мочевой пузырь и возможных механизмах реализации его терапевтического действия, основана на понимании общебиологических механизмов и позволяет как лучше объяснить результаты предшествующих клинических исследований, так и оценить перспективы расширения области дальнейшего применения препарата.

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Мочевой пузырь, инфравезикальная обструкция, патогенез дисфункции мочевого пузыря, serenoa repens, оксидантный стресс

Короткий адрес: https://sciup.org/142239010

IDR: 142239010   |   DOI: 10.29188/2222-8543-2023-16-2-16-30

Список литературы Гипотеза о возможных механизмах терапевтического действия гексанового экстракта Serenoa repens на состояние гипертрофированного мочевого пузыря в соответствии с патогенезом его дисфункции при инфравезикальной обструкции

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