Hormones of the pituitary-adrenal system and gastrointestinal tract in overweight young people

Aim. The paper aims to measure the plasma levels of adrenal and gastrointestinal hormones in overweight young people. Materials and methods. Male subjects were divided into 2 groups depending on their body mass index (BMI). The first group involved male subjects with a BMI > 18.5 and 2 (normal body weight), the second - with a BMI > 25 and 2 (excess body weight). Hormone plasma levels were measured with enzyme immunoassay. Results. During the academic year, hormone plasma levels were associated with BMI. In overweight young people, cortisol levels were higher compared to the subjects of the same age with normal body weight. Aldosterone secretion was less dependent on ACTH levels and was lower compared to subjects with normal body weight. CCK and gastrin levels were associated with BMI, gastric secretion and study conditions. Сonclusion. The modulation of adrenal and gastrointestinal hormones is associated with BMI. Thus, gastrin and cortisol levels were higher in overweight subjects, while CCC levels were lower compared to the control group. The identified patterns can be considered as a predisposing factor for further weight gain.