The nature of biliary tract motor disorders and liver function disorders in patients with chronic acalculous cholecystitis

The objective of the paper is to study the nature of biliary tract dyskinetic disorders and to determine their influence on the liver function impairment in patients with chronic acalculous cholecystitis. Materials and Methods. The authors examined 83 patients aged from 18 to 65 with chronic acalculous cholecystitis and 30 healthy people from a comparable age-sex group. The study included clinical data assessment, laboratory and instrumental methods of diagnosing the hepato-biliary system. Results. The main syndrome for patients with chronic acalculous cholecystitis pattern was characterized by a dull pain in the right upper quadrant spreading to the epigastric region and the left upper quadrant. Instrumental methods of diagnosis revealed inflammatory changes in the gallbladder walls and its deformation, dyskinetic biliary disorders, and hepatocyte function impairment slowing the liver excretory function. The laboratory tests revealed asymptomatic manifestations of cytolysis and cholestasis. Conclusions. Liver functional impairment was found in patients with chronic acalculous cholecystitis, deformation of the gallbladder, thickening and induration of its walls, dyskinesia of the gallbladder and sphincter apparatus of the biliary tract. Biliary tract dyskinesia in patients with chronic acalculous cholecystitis demonstrated the dominance of parasympathetic autonomic regulation, high state and trait anxiety levels and depression.