Chronic endometritis in the context of infertility and miscarriage

The objective of the study is to compare morphological and immunohistochemical diagnostic techniques for treating women with infertility and miscarriage. Materials and Methods. 69 women with infertility (1stgroup) and 36 women with miscarriage (2ndgroup) were examined during the trial. All women underwent Pipelle endometrial biopsy or endometrial aspiration biopsy with further morphological, immunohistochemical and bacteriological examination. Results. Immunohistochemical diagnostic technique is highly specific and sensitive. It allows not only to identify the type of infectious agent but also to determine the stage of the process. Chronic endometritis and precipitated morphological changes are the main reasons for infertility and miscarriage. The frequency of this pathology is 72.5±5.4 % for the patients with infertility and 86.1±5.8 % for the women of reproductive age (24-35 years old) with miscarriage (р>0,05). The disturbance of endometrial receptor mechanism is detected almost in all patients(in both groups) with chronic endometritis. Conclusion. Chronic endometritis isn't always accompanied by damaging microbial component. It is often due to viral invasion, which is very difficult to identify.