Immunological markers for predicting the protracted course of adjustment disorder in women with hypothyroidism

Introduction. The clinical and dynamic aspect of adjustment disorder has not been sufficiently studied. The course of this disorder is influenced by comorbid physical pathology, including thyroid disease. Associations have been established between hypothyroidism and a number of mental disorders that are masked by manifestations caused by a deficiency of thyroid hormones. This complicates the diagnosis of both endocrine and mental pathology, aggravates the course of the disease and delays the recovery period. The nervous, immune and endocrine systems function as a single complex of response to changes in the environment. The significant role of their close relationship in adjustment disorder and other nonpsychotic mental disorders is shown. The interaction between these systems determines many features of the pathogenesis of thyroid diseases, as well as the formation and course of nonpsychotic mental disorders.