In silico and in vivo study of the anti-inflammatory activity of azomethine derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide and 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3h)-one

Introduction. Azomethines and pyrimidines constitute an extensive class of organic compounds that can exhibit various types of biological activity, particularly anti-inflammatory effects. The search for effective and low-toxicity substances with anti-inflammatory properties is an urgent goal in pharmaceutical research, as the pathological process of inflammation is involved in numerous diseases. The aim of this work was to search for new compounds with pronounced anti-inflammatory effects among azomethine and pyrimidine derivatives. The objects of the study were azomethine derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide (3a-3s) and their corresponding 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one (4a-4s).