Индуцибельная NO-синтаза как фармакологическая мишень противовоспалительной терапии: надежда не потеряна?

Индуцибельная NO-синтаза как фармакологическая мишень противовоспалительной терапии: надежда не потеряна?

Автор: М.М. Галагудза, Ю.П. Бельский, Н.В. Бельская

Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk

Рубрика: Обзоры и лекции

Статья в выпуске: 1 т.38, 2023 года.

Бесплатный доступ

Обзор посвящен текущему пониманию роли оксида азота (NO) и индуцибельной NO-синтазы в физиологических условиях и при некоторых патологических состояниях. Рассмотрены механизмы индукции экспрессии гена индуцибельной NO-синтазы и посттранскрипционной регуляции активности индуцибельной NO-синтазы, приведены сведения об эндогенных ингибиторах индуцибельной NO-синтазы. Проведен анализ статуса клинических исследований, направленных на изучение клинической эффективности ингибиторов NO-синтаз.

Оксид азота, ингибитор индуцибельной синтазы оксида азота, доклинические исследования, клинические испытания

Короткий адрес: https://sciup.org/149141576

IDR: 149141576   |   DOI: 10.29001/2073-8552-2023-38-1-13-20

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