Infectious pathology of the reproductive tract in pregnant women

Aim. To evaluate the incidence and structure of infectious diseases of the reproductive tract of pregnant women and its effect on the course and outcome of pregnancy. Materials and Methods. 327 pregnant women were selected by continuous sampling method. The research involved clinical laboratory, instrumental, microbiological, and pathomorphological methods of study. After delivery, depending on the pathological study follow-up results all women were divided into two groups: I (basic) - 130 women with morphologically verified intrauterine infection (IUI), II (comparison) - 197 women without inflammatory changes in the afterbirth. There was conducted a comparative analysis of clinical and anamnestic data, of additional survey results, as well as perinatal outcomes of women in both groups. Results. In 80% of pregnant women infectious diseases of the lower reproductive tract were found, the most common form of which was cervicitis (54 %). The inflammatory process in the cervix can be seen as one of the markers of a possible implementation of IUI in pregnant women. Morphologically confirmed IUI was established in 39.8% of cases of all sorts and in 77.8 % - among premature delivery cases. In premature delivery IUI was presented by histological forms, reflecting the inflammatory process in the tissue of the placenta, which has more substantial length and depth. Only 40 % of IUI during pregnancy was accompanied by a systemic inflammatory response. Conclusion. Along with cervicitis, significant markers indicating a high risk of having IUI during pregnancy include burdened obstetric and gynecological anamnesis, persistent threat of pregnancy termination, changes in the structure of the fetoplacental complex at ultrasound violation utero-fetal blood flow, and prothrombotic state of homeostasis. Accounting for these markers will allow the justification of approaches to pathogenetic treatment of this complication.