Inhibin a and human в-chorionic gonadotropin as predictors of early pre-eclampsia at 16-18 weeks of pregnancy

The aim of the study was to examine the levels of human ß-chorionic gonadotropin (β-hCG) and inhi-bin A, as prognostic criteria for the development of early pre-eclampsia at 16-18 weeks of pregnancy. Materials and Methods. The prospective study included 60 patients with singlet pregnancies who underwent their first prenatal screening at 11-13 weeks. The patients were selected from 300 patients using continuous sampling method. According to the gestation course and outcome, the patients were divided into 2 groups: group 1 included 45 women with uncomplicated birth, group 2 consisted of 15 women with pre-eclampsia which developed before the 34th week. Based on calculations of the individual preeclampsia risks up to the 34th week of pregnancy according to the results of Astraia program (>1:300), women at 16-18 weeks of pregnancy underwent additional examination to determine inhibin A and ß-hCG. Results. In both groups, burdened obstetric and somatic anamnesis prevailed...