Innovative approaches to development of geroprotectorsphytoadaptogens for preventive oncology and age-related pathologies

1 – Federal State Budgetary Institution “National Medical Research Center of Oncology named after N.N. Blokhin” of the Ministry of Health of Russia, Moscow; 2 – Federal State Budgetary Institution “Scientific Research Institute of General Pathology and Pathophysiology”, Moscow; 3 – Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow; 4 - Federal State Budgetary Scientific Institution "All-Russian Research Institute of Medicinal and Aromatic Plants", Moscow; 5 – Scientific Research Institute of Biomedical Chemistry named after V.N. Orekhovich, Moscow, Russia

At the present stage, the problems of preventive oncology are becoming more and more important, especially, at the stages of blastomogenesis, recurrence and metastasizing of tumors. Preventive measures can also be aimed at regulating the stress syndrome, improving the efficiency and safety of chemoradiotherapy, and improving the quality of life and rehabilitation processes for cancer patients. Promising in this aspect are approaches, which take into account the unique capabilities of natural antitumor geroprotectors: phytoadaptogens (PhA) [1].

The use of appropriate methods and techniques, including computer methods, makes it possible to identify probable pharmacotherapeutic effects as well as the mechanisms of action of individual phytocomponents and their combinations, which makes it possible to optimize the use of PhA, taking into account the pleiotropy of actions. Scientifically substantiated and relevant are studies of phytocomplexes based on the principle of a rational combination of structurally diverse biologically active substances and providing unique synergistic effects that cannot be obtained with each individual ingredient separately. Moreover, the use of several adaptogens in the same pharmaceutical composition allows you to influence the body without inducing addiction. Taking into account the centuries-old experience of traditional folk medicine in many countries, the results

Conference Proceedings of domestic and foreign studies, considering the capability of PhA to correct adhesive dysregulation, which is the key factor in blastomogenesis [2,3], we have studied innovative approaches to the design and development of complex geroprotectors-phytoadaptogens with high efficiency and safety. Our research opens up prospects for the design and development of geroprotective drugs for the prevention and treatment of neoplasms, age-related pathologies as well as increasing human life expectancy.