Insulin-like growth factors and their binding proteins in the heart in rats in experimental diabetes mellitus, growing Guerin's carcinoma and under their combination

Insulin-like growth factors and their binding proteins in the heart in rats in experimental diabetes mellitus, growing Guerin's carcinoma and under their combination

Автор: Frantsiyants E.M., Bandovkina V.A., Kaplieva I.V., Surikova E.I., Cheryarina N.D., Shikhlyarova A.I., Neskubina I.V., Pogorelova Y.A., Trepitaki L.K., Goroshinskaya I.A., Kotieva I.M., Morozova M.I.

Журнал: Cardiometry @cardiometry

Статья в выпуске: 18, 2021 года.

Бесплатный доступ

Diabetes mellitus is an additional risk factor for the development of heart diseases, cardiovascular dysfunction and malignant tumors. The aim of the study was to analyze levels of IGF and IGFBP in heart samples of animals with diabetes mellitus and/ or growing Guerin’s carcinoma. The study included white outbred rats of both genders weighing 180-220 g. The rats of each gender were divided into groups of 8 animals: the intact group; test groups 1 (with diabetes) and 2 (with transplanted Guerin’s carcinoma); the main group (transplanted Guerin’s carcinoma growing in the presence of diabetes mellitus). Levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-2 were measured by ELISA (Mediagnost, Germany) in heart homogenates in animals of all groups

Еще

Diabetes mellitus, guerin's carcinoma, heart, igf, igfbp

Короткий адрес: https://sciup.org/148321606

IDR: 148321606   |   DOI: 10.18137/cardiometry.2021.18.138144

Список литературы Insulin-like growth factors and their binding proteins in the heart in rats in experimental diabetes mellitus, growing Guerin's carcinoma and under their combination

  • Crisafulli A, et al. Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning. Int J Mol Sci. 2020 Apr 21;21(8):2896. doi: 10.3390/ijms21082896.
  • Huth C, et al. Biomarker-defined pathways for incident type 2 diabetes and coronary heart disease-a comparison in the MONICA/KORA study. Cardiovasc Diabetol. 2020 Mar 12;19(1):32. doi: 10.1186/s12933-020-01003-w.
  • Kit OI, et al. Neoangiogenesis and fibrinolityc system biomarkers expression in the dynamics of experimental kidney ischemia in rats/ Eksperimental'naya i klinicheskaya urologiya. 2015;1:20-3. [in Russian]
  • Zhukova GI, et al. Effekty kombinirovannogo vozdejstviya nizkointensivnogo elektromagnitnogo izlucheniya millimitrovogo diapazona i kompleksov nezamenimyh aminokislot u krys-opuholenositelej starcheskogo vozrasta. YUzhno-rossijskij onkologicheskij zhurnal. 2020;1(4):38-46 [in Russian]
  • Kit OI, et al. Processy samoorganizacii mitohondrij pri roste eksperimental'nyh opuholej v usloviyah hronicheskoj nejrogennoj boli. Izvestiya vysshih uchebnyh zavedenij. Severo-Kavkazskij region. Seriya: Estestvennye nauki. 2019;2 (202):97-105 [in Russian]
  • Rudenko MY, et al. Cardiometry. Fundamentals of theory and practice. Taganrog, Moscow: ICM Publishing House, 2020. 215p. [in Russian]
  • Abudawood M. Diabetes and cancer: A comprehensive review.J Res Med Sci. 2019 Oct 25;24:94. doi: 10.4103/jrms.JRMS_242_19.
  • Wingard MC, Frasier CR, Singh M, Singh K. Heart failure and diabetes: role of ATM. Curr Opin Pharmacol. 2020 Oct;54:27-35. doi: 10.1016/j.coph.2020.06.007.
  • Dunlay SM , et al. On behalf of the American heart association heart failure and transplantation committee of the council on clinical cardiology; council on cardiovascular and stroke nursing; and the heart failure society of America type 2 diabetes mellitus and heart failure Circulation, 140 (2019), pp. 294-324
  • Jia G, Hill MA, Sowers JR. Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity. Circ. Res. 2018;122:624–638. doi: 10.1161/CIRCRESAHA.117.311586
  • Coller HA. Is cancer a metabolic disease? Am. J. Pathol. 2014;184:4–17. doi: 10.1016/j.ajpath.2013.07.035.
  • Blyth AJ, Kirk NS, Forbes BE. Understanding IGF-II Action through Insights into Receptor Binding and Activation. Cells. 2020 Oct 12;9(10):2276. doi: 10.3390/cells9102276.
  • Mohan S , Baylink D J IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms J Endocrinol. 2002 Oct;175(1):19-31. doi: 10.1677/joe.0.1750019.
  • Russo VC, Azar WJ, Yau SW, Sabin MA & Werther GA 2015 IGFBP-2: the dark horse in metabolism and cancer. Cytokine and Growth Factor Reviews 26 329–346. (https://doi.org/10.1016/j.cytogfr.2014.12.001)
  • Aghdam SY, Kenchegowda D, Sharma NK, Holmes- Hampton GP, Legesse B, Moroni M, Ghosh SPDysregulated Cardiac IGF-1 Signaling and Antioxidant Response Are Associated with Radiation Sensitivity. Int J Mol Sci. 2020 Jul 17;21(14):5049. doi: 10.3390/ijms21145049.
  • Kit OI, et al. The effect of chronic neurogenic pain on the course of malignant melanoma B16/F10 in male mice. Proceedings of higher educational institutions of the North Caucasus region. Natural Sciences 2019;1:106-11 [in Russian]
  • Sidorenko YS, et al. Method for obtaining experimental malignant lung tumors Patent for the invention RU 2375758 C1, 10.12.2009. Application no. 2008133091/14 dated 11.08.2008. [in Russian]
  • Dyrka K, Rozkiewicz N, Obara-Moszynska M, Niedziela M. The influence of growth hormone therapy on the cardiovascular system in Turner syndrome. J Pediatr Endocrinol Metab. 2020 Nov 26;33(11):1363-1372. doi: 10.1515/jpem-2020-0266.
  • Chanson P. The heart in growth hormone (GH) deficiency and the cardiovascular effects of GH. Ann Endocrinol (Paris). 2020 Mar 4:S0003-4266(20)30040-8. doi: 10.1016/j.ando.2020.03.005.
  • El Khoudary SR, et al; American Heart Association Prevention Science Committee of the Council on Epidemiology and Prevention; and Council on Cardiovascular and Stroke Nursing. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association. Circulation. 2020 Dec 22;142(25):e506-e532. doi: 10.1161/CIR.0000000000000912.
  • Bruno C, et al. Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial Dysfunction. Front Endocrinol (Lausanne). 2020 May 12;11:281. doi: 10.3389/fendo.2020.00281)
  • Back K., et al. Insulin and IGF1 receptors in human cardiac microvascular endothelial cells: Metabolic, mitogenic and anti-inflammatory effects. J. Endocrinol. 2012;215:89–96. doi: 10.1530/JOE-12-0261
  • Sui Y, et al. Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice. Stem Cell Res Ther. 2020 Feb 26;11(1):86. doi: 10.1186/s13287-020-1575-4.
  • Prelevic V, et al. Decreased insulin-like growth factor-1 (IGF-1) concentration correlates with reduced left-ventricle ejection fraction (LVEF) in hemodialysis patients.Int Urol Nephrol. 2020 Dec;52(12):2385-2391. doi: 10.1007/s11255-020-02595-8.
  • Takano APC, Senger N, Barreto-Chaves MLM. The endocrinological component and signaling pathways associated to cardiac hypertrophy. Mol Cell Endocrinol. 2020 Dec 1;518:110972. doi: 10.1016/j.mce.2020.110972.
  • Zhou H, Dickson M E., Kim MS, Bassel-Duby R, Eric N. Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes Proc. Natl. Acad. Sci. U.S.A., 112 (2015), pp. 11864-11869, https://doi.org/10.1073/pnas.1516237112
  • Hu Q, Zhou Y, Ying K, Ruan W. IGFBP, a novel target of lung cancer? Clin Chim Acta. 2017 Mar;466:172-177. doi: 10.1016/j.cca.2017.01.017.
  • Hoeflich A, Russo VC. Physiology and pathophysiology of IGFBP-1 and IGFBP-2 - consensus and dissent on metabolic control and malignant potential. Best Pract Res Clin Endocrinol Metab. 2015 Oct;29(5):685-700. doi: 10.1016/j.beem.2015.07.002.
  • Bach LA. IGF-binding proteins. J Mol Endocrinol. 2018 Jul;61(1):T11-T28. doi: 10.1530/JME-17-0254.
Еще
Статья научная
SciUp 2024 © 2024 ©