Insulin-like growth factor-1 in acute kidney injury in patients with coronary artery disease

Objective. The objective of this paper is to analyze the levels of insulin-like growth factor-1 (IGF-1) in blood plasma from patients with acute kidney injury in acute coronary pathology. The authors also examined the evaluation of clinical and prognostic value of IGF-1 in acute coronary syndrome. Materials and Methods. Concentrations of IGF-1 were measured in 71 patients with acute coronary syndrome, as well as in control and experimental groups. Results. The highest IGF-1 level was identified in patients with unstable angina. It was 1.12 times higher than that in patients with myocardial infarction. IGF-1 levels in acute myocardial infarction were lower than those in control and experimental groups, and higher than those in fatal cases. The lowest IGF-1 levels were measured in fatal cases. Correlation of IGF-1 with indices of renal function demonstrated the systemic nature of protein and possibility to extend diagnostic spectrum of IGF-1, for example, in order to verify renal pathology. Conclusion. IGF-1 levels in acute coronary syndrome are of clinical prognostic value. IGF-I is a growth hormone, which contributes to the reparation of vascular walls. In terms of cardiovascular continuum reparative role of IGF-1 is systemic in nature. IGF-1 has a favorable effect on heart, vessels and kidney. IGF-1 is a new highly sensitive biochemical marker of vascular inflammation and damage. It can be used in laboratory diagnostics of acute coronary syndrome.