Integral haematological indices and homocysteine in posthepatectomy liver failure

Background. The increase in the volume and number of hepatic surgeries is causing a rise in the frequency of postoperative complications, such as acute posthepatectomy liver failure.Aim. This article investigates changes in integral haematological indices and plasma homocysteine depending on the degree of development of posthepatectomy liver failure.Materials and methods. The article presents the results of the study of the value of leukocyte indices of cellular reactivity and plasma homocysteine level in 40 patients with different classes of acute posthepatectomy liver failure (PHLF). Patients were divided into three groups: those with postoperative class A, B and C PHLF. Data were analysed before surgical intervention, postoperatively and upon discharge.Results. A comparison of the average leukocyte indices in groups B and C of PHLF before surgery, postoperatively and upon discharge revealed a rise in most metrics. The notable increase in indicators of the progression and extent of endotoxicosis and inflammatory response suggests their potential use as screening markers for diagnosing and predicting this complication. Moreover, the considerable rise in plasma homocysteine levels in B and C PHLF groups during the postoperative phase indicates a disruption in the synthesis of the acid and correlates with functional liver failure.Conclusion. The haematological intoxication indices and plasma homocysteine levels ensure early detection of inflammatory response development and are diagnostically significant in identifying acute PHLF.