Integral parameters of white rats with prolonged use of a complex remedy from natural raw materials

The purpose of this article was to study the possible toxic effect of a new complex agent with its long-term parenteral use in laboratory rats. The criteria for assessing the manifestation of negative consequences in this series of experiments were such indicators as the mass of internal organs, body weight in dynamics, as well as an organ-weight coefficient that allows determining the target organ during the development of a toxic effect. During the research, it was found that when injecting the drug in doses of 0.1, 0.5 and 1.0 ml for 30 days, the safety of experimental animals was 100%, and the mass of internal organs at the final stage of the experiment did not differ from control analogues. At the same time, we noted the lowest average daily body weight gain in the group of animals with the highest dose of the drug, which was 0.6 g.