Ирисин как посредник и маркер позитивных эффектов физической активности: физиологические основы методов реабилитации

Автор: Глазачев О.С., Крыжановская С.Ю., Запара М.А., Ледень А.С.

Журнал: Человек. Спорт. Медицина @hsm-susu

Статья в выпуске: 3 т.24, 2024 года.

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Цель: проанализировать данные литературы о механизмах действия ирисина, регуляции и возможных методах стимуляции секреции. Методы исследования. Анализ публикаций за последние 5 лет баз данных PubMed и eLibrary.ru. Результаты. Показаны аутокринные и паракринные эффекты ирисина на мышцы и эндокринные эффекты на другие органы. В целом ирисин поддерживает баланс между мышечной, костной и жировой тканями, оказывает противодиабетическое действие и препятствует ожирению, когнитивным и сосудистым нарушениям, сопровождающим уменьшение мышечной массы при недостатке физической активности (ФА). Продемонстрированы возможности детекции ирисина как маркера саркопении. Учитывая данные о регуляции секреции ирисина, разрабатываются технологии стимуляции его синтеза, доступные при вынужденном дефиците ФА. Среди них – сбалансированное питание, альтернативные виды тренировок, электроакупунктура, температурные воздействия. Большой интерес вызывают методы прогревания ввиду достаточной теоретической базы их применения. Заключение. Ирисин оказывает множественные долгосрочные положительные эффекты у здоровых людей и при патологии. Физиологически обосновано использование методов реабилитации для стимуляции секреции ирисина, причем тепловые воздействия эффективны как в сочетании с ФА, так и без нее.

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Миокины, ирисин, физическая активность, саркопения, методы реабилитации

Короткий адрес: https://sciup.org/147247667

IDR: 147247667 | DOI: 10.14529/hsm240308

Список литературы Ирисин как посредник и маркер позитивных эффектов физической активности: физиологические основы методов реабилитации

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