Research of biologically active substances of Coluria geoides (Rosaceae) dry extract, stimulating the cellular immune answer

On mice of CBA/CaLac line influence of fractions of Coluria geoides (Rosaceae) extract on various stages of cellular immune answer in reaction of hypersensitivity of the slowed-down type is investigated. The fraction of water-soluble biologically active substances most actively stimulated synthesis of pro-inflammatory cytokines at a stage of DTH resolution. As a part of fractions phenolic acids and flavonoids are identified. We consider extraction from dry C.geoides extract the complex of active ingredients inexpedient as whole extract has aggregate pharmacological effects of fractions.