Studies and comparative evaluation of the functional and material cumulation of nano and microdisperse nickel oxide consumed by the peroral route

The results of the research and comparative assessment of the cumulative properties of nanodisperse and microdisperse nickel oxide in the experiment are presented. It is found that after the intragastric gavage of the nanodisperse nickel oxide for 16 days (total dose administered was 16250 mg / kg) it possesses a functional accumulation, as it is evidenced by the morphological changes in the tissues of the gastrointestinal tract, liver, spleen, and material accumulation indicator which is an increase of its concentration in the brain, liver and kidneys relative to controls (4.7, 8.1 and 23.6 times, respectively). Microdisperse analague also has a functional and material accumulation, but the degree of manifestation is different from the accumulation of nanodisperse nickel oxide. The accumulation of the substance occurs only in brain and liver, and in lower concentrations as compared to the nanodisperse nickel oxide (1.7 and 3.6 times). The morphological changes of tissues of the gastrointestinal tract and the spleen are less pronounced, any change in liver tissue is not established.