Research of atorvastatin influence on the level of leptin, insulin, c-reactive protein and indicators of fats in blood serum of women with ischemic heart disease and obesity

The study data about the content of leptin, insulin, free fatty acids, cholesterol LDL and HDL Cholesterol in the blood serum of women with ischemic heart disease, arterial hypertension and obesity before and after 3 and 6 months of therapy with curative dose of 10 mg of atorvastatin are presented. Fifteen female patients and 12 healthy women were included into research. The content of leptin and insulin was defined using immunoenzyme method. C-reactive protein was studied with the help of direct fluorescence polarization immunoassay method. The level of free fatty acids was defined using colorimetric method. Cholesterol LDL was defined with the help of homogeneous method of direct measurement with selective protection, and HDL cholesterol - homogeneous method of direct measurement with immunoinhibition without sedimentation. Women with ischemic heart disease, arterial hypertension and overweight showed in the initial state the increase in the level of leptin, insulin, C-reactive protein, free fatty acids and cholesterol LDL compared to the group of healthy women. The content of HDL cholesterol was decreased as compared to the group of healthy volunteers. Three and six months of therapy with atorvastatin lead to decrease in the content of free fatty acids, cholesterol LDL and C-reactive protein, and increase in the content of insulin, but this therapy does not influence the content of leptin and HDL cholesterol in women with ischemic heart disease, arterial hypertension and overweight.