Research of the effect polymorphic variants of the DRD4 gene for development and progress Parkinson's disease

In this article, we presented research of effect polymorphic variants of the DRD4 gene (120 bp VNTR in 5’-UTR, 48 bp VNTR in 3 exon, -616C/G) for development and progress Parkinson’s disease. Established polymorphic variants of the gene are markers of risk (allel *7 48bp-VNTR in 3 exon) and protective markers (allel *2 48bp-VNTR in 3 exon) for development Parkinson’s disease for the residents of the Republic of Bashkortostan, most of the population which is represented by ethnic groups of Russian, Tatar and Bashkir. Identified the modifying effect of certain genotypes and alleles of the gene on the nature of the clinical course of disease.