Change allelotypes of BoLA-DRB3 gene in brucellosis-sick cows of auliekol breed in Kazakhstan

Healthy and brucellosis-sick cows of Auliekol breed from different regions of the Republic of Kazakhstan were studied by PCR-PLRF using DNA markers based on allelic polymorphism of the BoLA-DRB3 gene. In the groups of healthy animals and brucell carriers, 24 and 22 alleles were revealed, respectively, which indicates a sufficiently high genetic diversity of the livestock of the Auliekol breed of Kazakhstan. In healthy cows, the allele *3 is most common. There was revealed the presence of alleles of the gene BoLA-DRB3, characteristic for sick animals - *7, *10, *18, *36. These alleles may be associated with susceptibility to brucellosis of Auliekol animals.