Renin and aldosterone concentrations change depending on the arterial blood pressure long-term after renal denervation in patients with resistant hypertension

In recent years, the method of renal arteries transcatheter sympathetic denervation for treating patients with resistant hypertension has been used worldwide. At the same time, many questions about the procedure of hypotensive mechanisms and therapeutic effect duration still remain without answers. The effects of radiofrequency ablation of renal arteries are considered to occur through downregulation of sympathetic effects on the kidneys and decrease in renin-angiotensin-aldosterone system activity. Preclinical animal studies confirmed significant decreases in the renin and aldosterone levels after renal denervation along with lowering blood pressure. However, no data are available regarding the changes in the levels of these hormones in patients after the operative treatment. Long-term effects of catheter renal denervation remain also insufficiently explored.