The alterations of 24 hours' Profiles of arterial pressure in patients with arterial hypertension and syndrome of obstructive sleep apnoe

Significant value is lately given to PND as a factor which complicates cardiovascular diseases. The aim of this research was to study arterial hypertension course features as well as disturbance of circadian rhythms of blood pressure in patients with PND associated with hypertension. There were 20 PND patients with diagnosed with I-II stages of essential hypertension, as well as 1-2 degree with AH. Depending on PND severity level defined by apnea/hypopnea index (AHI) patients were split into 2 groups: group 1A containing 5 patients with mild case of PND (AHI 10-20 ep/hour) and the 1st stage of essential hypertension; group 1B containing of 15 severe case patients (AHI>40 ep/h) and 2nd stage of essential hypertension. Groups 2A and 2B included patients with I and II stages of essential hypertension accordingly not having PND. All patients have underwent polysomnography, 24-h ambulatory blood pressure monitoring, echocardiography, ECG and biochemical analyses. When comparing group 1A to 2A significant differences were observed: night systolic BP (123,38±11,41 mm Hg) exceeded an admissible norm and was higher than in 2A group (110,50±10,21 mm Hg; p2, respectively; p