Study of asymmetric dimethylarginine as endothelium dysfunction marker of type 1 diabetes mellitus in children

Endothelium dysfunction is considered a key sign in pathogenesis of microvascular complications of diabetes mellitus. Impairment of endothelium dependent vasodilatation is one of the main effects resulting from accumulation of asymmetric dimethylarginine. The purpose of the investigation is to determine characteristics of asymmetric dimethylarginine content in blood serum as endothelium dysfunction marker of type 1 diabetes mellitus in children. 135 children with type 1 diabetes mellitus at the age of 1-17 years old were examined. The control group consisted of 40 clinically healthy children at the same age and sex. Patients were divided into some groups depending on duration of the disease. Asymmetric dimethylarginine in blood serum was revealed in 40 children. Increase of asymmetric dimethylarginine levels was noted in children with history of type 1 diabetes mellitus more than 5 years.