Studying the embryotoxic effect of neostomosan

The aim of the work was to study the embryotoxic effect of the pyrethroid drug Neostomozan in order to confirm its safety and the possibility of use in animal husbandry and veterinary medicine. With repeated bathing of pregnant rats in Neostomosan 0.1 % concentration at different periods of rat pregnancy (from 1st to 6th days, from 6th to 16th days, from 16th to 19th days), it was found that the drug did not cause toxic effects in animals. The values of fetal development indicators in the antenatal period (preimplantation, postimplantation and total embryonic mortality) in the experimental groups did not significantly differ from the anological indicators of the control group. When studying the length and weight of embryos, fetal growth retardation was not detected. Upon examination of fetuses extracted from the uterus, no significant visible developmental abnormalities (deformities) were revealed. Also, when studying the internal organs of fetuses, no defects in their development were noted. A study of fetuses from females who bathed in Neostomosan in 0.1 % concentration at different periods of pregnancy showed that there were no skeletal development defects, which indicates that the drug does not cause a violation of the processes of bone tissue development. Based on the data obtained in the laboratory model experiment, it can be concluded that the pyrethroid drug Neostomozan 0.1 % concentration does not have embryotoxic and teratogenic effects.