Study of tumor-associated markers and some biochemical indicators in melanocytic skin formations

Objective. The purpose of the paper is to study and compare the level of tumor-associated proteins CD44 and S100, indicators of protein and lipid metabolism in melanocytic skin tumors. Materials and Methods. The authors examined 100 samples of 10 % homogenates of skin melanoma tissue, nevi, perifocal zone and resection line. CD44 and S100 levels were determined by enzyme immunoassay using standard test systems on a TECAN analyzer (Austria). The levels of total protein, cholesterol, triglycerides were determined on a ChemWell biochemical analyzer (USA). Results. A sharp increase in S100B level was detected in melanoma tissues, 28 times as high as in the samples of healthy tissue and nevi, as well as a significant, but less evident increase in the CD44 level, which was also observed in nevi tissue. The ratio of albumin and gamma globulins in melanoma and nevi tissues was 3-6 times lower if compared with healthy tissue, and the levels of cholesterol and triglycerides in melanoma were only a little higher than in healthy tissues and nevi...