The study of the acute toxicity of the kinmiks on white rats

This work was carried out to study the acute toxicity of the kinmiks on laboratory animals. The experiments were performed on 30 white rats with body weight of 180-200 g the animals were divided into 5 groups of 6 rats each. The kinmiks were administered intragastric to wats with doses of 15 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg and 100 mg/kg. The monitoring was conducted for 4 days, noting the clinical condition of the animals. The first clinical signs in animals occurred within 7 minutes after the introduction of the toxicant. Later after 10 minutes was observed incoordination. After 15-20 min. we observed a strong tremor, and profuse salivation, wheezing. At 35-45 minutes at the animal’s severe convulsions were developed (clonic and clonic-tonic), then they fell into a comatose state. They death came in 60-120 minutes. It was found that the dose of the kinmiks - 100 mg/kg - is absolutely fatal dose for white rats. Median lethal dose of kinmiks for white rats were amounted to 59.6±17.1 mg/kg, ЛД16 =32.1 mg/kg and ЛД84= 82.2 mg/kg.