Study of the profile of antibiotic resistance of autochtonous microorganisms

Diazotrophic, phosphate-mobilizing, and hydrocarbon-oxidizing autochthonous bacteria- Staphylococcus warneri, Pseudomonas stutzeri, Achromobacter xylosoxidans, Bacillus thuringiensis, Brevibacillus laterosporus, and Shinella zoogloeoides - were isolated from various soils of the Republic of Tatarstan, studied, and selected for the creation of biological preparations. The disk-diffusion method was used to determine the profile of antibiotic resistance in them. Twelve antibiotics were studied: azithromycin, ampicillin, kanamycin, chloramphenicol, nalidixic acid, novobiocin, ofloxacin, rifampicin, streptomycin, tetracycline, ciprofloxacin, and erythromycin. It has been established that each of the six strains has resistance to at least one antibiotic. Achromobacter xylosoxidans is resistant to the greatest number of antibiotics (4 out of 12). Only two strains, Bacillus thuringiensis and Brevibacillus laterosporus, are sensitive to erythromycin. Among the studied strains, resistance to azithromycin and fluoroquinolones (ofloxacin and ciprofloxacin) was not found, which makes these antibiotics the most promising in clinical practice.