Study of anti-cancer action of synthetic antioxidant on the cell line of breast cancer MCF-7

Synthetic antioxidants used to treat cancer are promising due to their low toxicity. The study compares in vitro cytotoxic and chemotherapeutic properties of synthetic antioxidants and the known drug doxorubicin in transferable cultures of breast cancer cells MCF-7 and epithelial cells of the embryo of cattle. Incubation of tumor cell line MCF-7 with the drug doxorubicin in a concentration of 3.7 mg/l led to the death of 50% of the cells at the same time, the percentage of normal cells LEC at the same dose of the substance amounted to 42 %. It was found that the drug 1 has a higher toxicity to the "normal" epithelial cell (IC100 more than 100 mg/l) than the tumor cell (IC100 400 mg/l); the maximum dose for these cells - 20 and 40 mg/l, respectively. The results of the study of drug 2 showed its similar toxicity to the cells of the LEK and MCF-7 lines, the lethal dose for the cells of both cultures was 400 mg/l.the generally Accepted chemotherapy drug doxorubicin had a weak therapeutic effect in doses from 3.0 to 25.0 mg/l. thus, we can say about the dose-dependent cytotoxic effect of the drug doxorubicin not only for cancer, but also for normal cells.