Study of irritant properties of triphenylphosphonium

The aim of this work was to study the irritant properties of phosphonium salt on laboratory rats to justify its use in veterinary medicine. In an in vivo experiment, the response of laboratory rats to the effects of phosphonium salt and the conjunctiva was determined. One drop of the test solution was dripped into the left eye, and distilled water in a similar dose was dripped into the right eye. When introducing, the inner corner of the conjunctival sac was pulled, then the lacrimal-nasal canal was pressed for 1 minute. During the observation period, no skin or physiological disorders were noted in the experimental animals. Signs of inflammation were not recorded. The skin had no signs of inflammation, did not differ in temperature from the temperature of other areas of the skin, and did not cause concern in the experimental animals. Signs of itching were not observed. We noted that after the introduction of the phosphonium salt solution, rats experienced slight reddening of the mucous membrane of the eye, lacrimation, which passed after 45 minutes. At the same time, no deviations from the norm were observed in the condition of the animals in the subsequent periods of the study. The obtained results indicate that phosphonium salt does not have a local irritant effect and does not affect the physiological state of the body of experimental animals.