Electroencephalographic biomarkers of experimentally induced stress

The results of the analysis of psychophysiological studies published abroad on the use of electroencephalographic (EEG) indicators as objective and reliable biomarkers of stress experimentally induced in subjects under laboratory conditions are presented. The main experimental protocols used to induce stress in healthy subjects are described. Based on the analysis of the published works, the main electroencephalographic stress biomarkers are highlighted and detailed possible perspectives of the use of these markers in clinical practice for the diagnosis of mental disorders and the formation of a group of targets for study under experimental conditions and therapy are presented. Principal limitations for using electroencephalographic biomarkers as the main diagnostic tool in fundamental scientific and applied research are analyzed. Some ideas about the prospects of further use of EEG data for studying the phenomenon of stress is given. It was shown that EEG and biomarkers of evoked potentials (EP biomarkers), along with clinical (neuroendocrine, immune, etc.) biomarkers and biomarkers obtained by using other methods of neuroimaging (positron emission tomography, PET and functional magnetic resonance imaging tomography, fMRI) are an informative tool for diagnosing stress and its consequences