Эпигенетические факторы сердечной недостаточности (обзор)

Эпигенетические факторы сердечной недостаточности (обзор)

Автор: Кучер А. Н., Назаренко М. С.

Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk

Рубрика: Обзоры и лекции

Статья в выпуске: 4 т.38, 2023 года.

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Сердечная недостаточность (СН) - широко распространенный синдром, приводящий к существенному снижению качества жизни пациентов. Одним из перспективных направлений в изучении СН является эпигенетика, позволяющая рассматривать патогенез данного синдрома на новом молекулярном уровне. Настоящей обзор посвящен обобщению исследований, связанных с изучением эпигенетических процессов (модификация гистонов, метилирование ДНК, изменение экспрессии регуляторных некодирующих РНК), сопровождающих развитие СН. Эпигенетические исследования СН не только подтвердили клиническую и этиологическую гетерогенность данного синдрома, но и расширили спектр маркеров, потенциально значимых для диагностики, а также открыли новые стратегии разработки лекарственных препаратов.

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Сердечная недостаточность, кардиомиопатии, эпигенетические факторы

Короткий адрес: https://sciup.org/149144444

IDR: 149144444   |   DOI: 10.29001/2073-8552-2023-38-4-61-69

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