Erythrocytic microrheological characteristics of patients with arterial hypertension and dyslipidemia under simvastatin and drug-free modalities

It is known that certain lipid-lowering drugs can affect the microrheological properties of blood cells in patients with hypertension and dyslipidemia. Also it is found out that physical activity has a positive effect on the functional characteristics of blood corpuscles. At the same time, the impact of lipid-lowering drugs combined with lipid-lowering diet and various types of physical activity on rheological properties of red blood cells of patients with arterial hypertension and dyslipidemia is still underexplored. The objective of the paper is to evaluate the effectiveness of a therapeutic complex, which consists of simvastatin and drug-free modalities, i.e. how it influences the rheological properties of red blood cells in patients with arterial hypertension and dyslipidemia. Materials and Methods. The study enrolled 55 middle-aged patients with arterial hypertension (1-2 degrees) with type IIb dyslipidemia, risk 4. The control group involved 26 healthy people of the same age. Biochemical, hematological and statistical diagnostic techniques were used. Results. Combination of simvastatin and drug-free modalities in patients with arterial hypertension and dyslipidemia improves blood plasma lipids in 12 weeks, whereas red blood cell lipids, lipid peroxidation in plasma and red blood cells improves in 6 weeks. Administration of simvastatin and drug-free modalities in patient normalizes their cytoarchitectonics and spontaneous red blood cell aggregation in 6 weeks. The results achieved last for at least 98 weeks of successive treatment. Conclusion. Combination of simvastatin and drug-free modalities normalizes the microrheological properties of red blood cells in patients with hypertension and dyslipidemia in 6 weeks.