The morphogenesis of the neuroleptic
Автор: V.P. Volkov
Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk
Рубрика: Клинические исследования
Статья в выпуске: 4 т.27, 2012 года.
Бесплатный доступ
The objective of the study was to elucidate the morphofunctional changes in the heart during development of neuroleptic induced cardiomyopathy (NICM) and to find associations between the morphofunctional cardiac changes and ECG abnormalities. Patients were assigned into three groups. The first group included 12 patients who received antipsychotic treatment without history of cardiac pathology (control group); the second group included 44 patients with subclinical NICM; and the third group consisted of 34 individuals who died of heart failure due to NICM. The morphometric study of myocardial changes and the analysis of 406 ECGs were performed. Data of the study showed that NICM development was associated with the pathologic changes in the myocardial extracellular matrix and microcirculation which resulted in dystrophy, degeneration and atrophy of cardiac myocytes. Progressive heart failure in patients with NICM was associated with ECG changes. The study showed close correlation between the changes in myocardial morphology and the ECG abnormalities. Data of this study contribute to the early NICM diagnosis and prevention.
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Neurolepticinduced cardiomyopathy, morphogenesis, morphofunctional correlations
Короткий адрес: https://sciup.org/14920268
IDR: 14920268
Статья научная
Автор: V.P. Volkov
Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk
Рубрика: Клинические исследования
Статья в выпуске: 4 т.27, 2012 года.
Бесплатный доступ
The objective of the study was to elucidate the morphofunctional changes in the heart during development of neuroleptic induced cardiomyopathy (NICM) and to find associations between the morphofunctional cardiac changes and ECG abnormalities. Patients were assigned into three groups. The first group included 12 patients who received antipsychotic treatment without history of cardiac pathology (control group); the second group included 44 patients with subclinical NICM; and the third group consisted of 34 individuals who died of heart failure due to NICM. The morphometric study of myocardial changes and the analysis of 406 ECGs were performed. Data of the study showed that NICM development was associated with the pathologic changes in the myocardial extracellular matrix and microcirculation which resulted in dystrophy, degeneration and atrophy of cardiac myocytes. Progressive heart failure in patients with NICM was associated with ECG changes. The study showed close correlation between the changes in myocardial morphology and the ECG abnormalities. Data of this study contribute to the early NICM diagnosis and prevention.
Neurolepticinduced cardiomyopathy, morphogenesis, morphofunctional correlations
Короткий адрес: https://sciup.org/14920268
IDR: 14920268
