Kinetics of sulphanilamide release from polymer composite material for medical purpose based on acrylic hydrogels and detonating nanodiamonds

A polymer composite material for medical use was obtained, using the method of radical polymerization, based on acrylic hydrogels and detonation nanodiamonds, containing the drug sulfanilamide, which can become a replacement for traditional dressings. The swelling kinetics of the synthesized hydrogel was studied. Mathematical models that best describe the process of sulfonamide desorption and swelling kinetics have been proposed. Based on the research results, a pseudo-second order model was chosen to describe the swelling process. The kinetics of sulfonamide release was studied using UV spectroscopy based on an analysis of the dependence of the concentration of the released drug on time. An assumption has been made about the mechanism of the process of desorption of a medicinal substance from a hydrogel matrix. During the experiment, the maximum proportion of sulfonamide released from the polymer matrix was calculated (it amounted to 91%). The time for the dependence of the proportion of released drug on time to reach a plateau was 24 hours. Based on the data obtained, an assumption about the possibility of creating a prolonged form of sulfonamide based on the synthesized composite material was made. The Korsmaier-Peppas model was chosen to describe the release process based on the highest coefficient of determination. pH values were selected corresponding to different stages of the wound process (7.9, 7.2, 5.8). The effect of pH on the kinetics of sulfonamide release and on the swelling of the hydrogel was studied. The mechanical properties of hydrogels were studied using oscillatory rheometry methods. The dependences of the dynamic modules on amplitude were obtained. The influence of the filler (detonation nanodiamonds) and the drug substance on the values of dynamic moduli is shown.