Cell cardiomyoplasty in the surgical treatment of patients with coronary artery disease and postinfarction cardiosclerosis: results of the threexyears observation

The aim of the work is to estimate the effect of coronary bypass graft using cell cardiomyoplasty withing the 3-years observation. 66 patients are involved into the study, mean age 41-64 years old with coronary artery disease and postinfarction cardiosclerosis. I group - 38 male patients, with coronary artery bypass together with cell cardiomyoplasty and II group (control) - 28 male patients who experienced only surgical treatment. 40 patients later were included into the prospective study. All patients underwent echocardiography, single photon emission computed tomography of myocardiaum with Thallium-199, microscopic examination of biopsy material. Six mounth later we found surgical treatment to have the best clinical effect. Most patients experienced a decrease in the functional class of angina and circulatory inefficiency according to NYHA. Both groups showed statistically significant amelioration of systolic left ventricular function and increase of ejection fraction, all these without significant differences between groups. The actuarial survival rate by the end of the 3-year period was 80%.