Клеточные и гуморальные механизмы регенерации почки

Автор: Кирпатовский В.И., Соколов М.А., Рабинович Э.З., Сивков А.В.

Журнал: Экспериментальная и клиническая урология @ecuro

Статья в выпуске: 2, 2017 года.

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Целью статьи является проведение анализа современной литературы по изучению механизмов регенерации почки при ее ишемическом или токсическом повреждении. В обзоре проанализированы данные о наличии и идентификации стволовых/ прогениторных клеток в почке взрослого организма. Установлено наличие этих клеток в различных почечных структурах (клубочках, канальцах). Однако их ведущая роль в регенерации поврежденных почечных структур в последние годы стала подвергаться сомнению. Накапливаются данные, что не менее важную роль играет процесс де-дифференцировки зрелых почечных клеток с их последующей пролиферацией и дифференцировкой в соответствующие клеточные линии (подоциты, эпителиоциты, эндотелиоциты). Обсуждаются механизмы, запускающие этот процесс, в том числе воздействие компонентов погибших клеток, а также влияние активации резидентных стволовых клеток и продуктов их секреции. Анализируется также роль нарушения микроциркуляции при ишемическом или токсическом повреждении почек и участие в этом процессе перицитов, а также влияние клеточной терапии на восстановление микроциркуляции и регенераторный потенциал поврежденного органа. Также проанализирована терапевтическая эффективность использования клеточной терапии или биологически активных компонентов, секретируемых стволовыми/прогениторными клетками в восстановлении функции поврежденной почки. При этом показано, что эффективность продуктов секреции стволовых/ прогениторных клеток, полученных в результате их культивирования (так называемый «секретом»), не уступает эффективности использования самих клеток.

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Почка, регенерация, стволовые/прогениторные клетки, клеточная терапия, регенеративная медицина

Короткий адрес: https://sciup.org/142188184

IDR: 142188184

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